Primary Role:

The primary role of this position is to generate key data for Proof of Concept (POC) and early developability assessment for research molecules. This position will be designing and conducting biophysical and biochemical experiments for molecular selection by screening for functional and developability attributes including preformulation. Knowledge and experience in protein biochemistry and characterization techniques including MassSpec, SPR and octet based binding are essential. Experience in glycobiology, antibody engineering, preformulation/formulation of biotherapeutics are desirable.

The responsibilities for this role include planning, designing and execution of experiments using biophysical and biochemical methodologies; interpreting and presenting scientific data that contribute to our understanding of candidate molecules for PoC. This candidate will also manage CROs to provide analytical support needed for project teams. Also expected to explore new technologies to characterize recombinant/engineered macromolecules and molecular interactions and preformulation/formulation screening, in alignment with department goals.

Success in this role is measured by the ability to provide strategically relevant, scientifically reliable information that supports the Company goals.

No budgetary responsibility is required for this role. Expected to train and supervise other team members and manage projects.

Good candidates should possess the capability of design and execute scientific experiments independently, demonstrated problem solving, and trouble-shooting skills. Attention to detail is essential. A good candidate should have an excellent team oriented spirit that is demonstrated by working toward common business goals with fellow scientists. The candidate needs to be flexible with assignments and adaptable to the changing needs of projects and the group. Good communication skills are required.

Responsibilities:

70% Planning and performing scientific experiments

10% Train fellow scientists with analytical techniques, manage CROs and explore new technologies for analytical characterization

10% Communicate with supervisor and fellow scientists regarding experimental design and results.

10% Prepare research reports and summary.

Education and Experience:

A Ph.D. in Life Sciences with emphasis on MassSpec, Biophysics, Physical Chemistry or Biochemistry is required. 1-5 years of combined academic/industry experience in macromolecules, especially in proteins and antibodies research, is required.

Key Skills and Competencies:

The person is expected to support projects that are conducted in Research by performing literature searches, plan and execute research experiments and propose new strategies for biophysical and biochemical screening assays. This person is responsible for designing and executing scientific experiments to generate key analytical data for the project teams.

In-depth knowledge in molecular characterization including screening approaches of various through-put, protein-protein interactions and protein engineering are essential.

Knowledge in kinetic, thermodynamics, spectrometry and other biophysical properties of macromolecules, especially proteins and antibodies is required. Knowledge and experience in, Bio-Layer Interferometry (BLI), Surface Plasmon Resonance (SPR), Light Scattering, and Calorimetric techniques are required. This person is expected to work independently to carry out research experiments using the above mentioned techniques. This person should demonstrate sound judgment in analysis of experimental data and in trouble-shooting.

Fluent and clear verbal and written communication is required. Regular updates in group meeting are expected.

Basic computer skills, including Excel, Microsoft Words and PowerPoint for data analysis, writing reports and presenting data, are required. Computer skills in instrumental controls are required.

This person is expected to be in compliance with company policies in keeping good record. This person is expected to write reports upon projects completion.

This person must be a team player, must be able to play either a leading role or an assisting role depending on project needs. This person must be self-motivating and hard-working. Attention to detail is required.

Internal and External contacts:

This position will have frequent contacts with fellow scientists in Research and Non-clinical Development and Process Development departments.

This person will be involved in project team meetings and acts as representative of Analytical Research group. This person will also be involved in contact with vendors for instruments repairs and CROs for out sourced projects.

Other Job requirements:

Compliance to general lab safety, biohazard, radiation hazard and chemical hazard regulation is required.